Co-occurrence of odor-causing dioxanes and dioxolanes with bis(2-chloro-1-methylethyl) ether in Huangpu River source water and fates in O 3-BAC process

In recent years, dioxanes and dioxolanes have been intermittently detected in water environment and have caused several offensive drinking water odor incidents worldwide. In this study, the co-occurrence of eight dioxanes, twelve dioxolanes and bis(2-chloro-1-methylethyl) ether was investigated in Huangpu River watershed to explore potential sources and contributions to septic/chemical odor. Totally 8 dioxanes and dioxolanes were detected in river, with 1,4-dioxane (212 -8310 ng/L) and 2,5,5-trimethyl-1,3-dioxane (n.d.-133 ng/L) as the dominated dioxanes, 2-methyl-1,3-dioxolane (49.5 -2278 ng/L), 2-ethy-4-methyl-1,3-dioxolane (n.d.-167 ng/L) and 1,3-dioxolane (n.d.-225 ng/L) as the major dioxolanes.
Bis(2-chloro-1-methylethyl) ether was detected (n.d.-1094 ng/L) with significant correlation with dioxanes and dioxolanes, illustrating their similar polyester resin-related industrial origins. 2-Ethy-4-methyl-1,3-dioxolane, 2,5,5-trimethyl-1,3-dioxane and bis(2-chloro-1-methylethyl) ether with individual maximum odor activity value above 1, should contribute to septic/chemical odor in Huangpu River water. The increased concentrations of these chemicals in the downstream of some industrial areas illustrated the association with industrial discharge.
Fates in a waterworks using the river water as source water were further explored. The adopting ozone-biological activated carbon treatment could permit a relatively high removal for bis(2-chloro-1-methylethyl) ether and 2,5,5-trimethyl-1,3-dioxane (> 80%), while limited removal for other chemicals. This study provides valuable information for the management of drinking source water and water environment.

Stereodefined alkenes with a fluoro-chloro terminus as a uniquely enabling compound class

Trisubstituted alkenyl fluorides are important compounds for drug discovery, agrochemical development and materials science. Despite notable progress, however, many stereochemically defined trisubstituted fluoroalkenes either cannot be prepared efficiently or can only be accessed in one isomeric form. Here we outline a general solution to this problem by first unveiling a practical, widely applicable and catalytic strategy for stereodivergent synthesis of olefins bearing a fluoro-chloro terminus.
This has been accomplished by cross-metathesis between two trisubstituted olefins, one of which is a purchasable but scarcely utilized trihaloalkene. Subsequent cross-coupling can then be used to generate an assortment of trisubstituted alkenyl fluorides. The importance of the advance is highlighted by syntheses of, among others, a fluoronematic liquid-crystal component, peptide analogues bearing an E- or a Z-amide bond mimic, and all four stereoisomers of difluororumenic ester (an anti-cancer compound).

Electrospun 5-Chloro-7-iodo-8-hydroxyquinoline (Clioquinol)-Containing Poly(3-hydroxybutyrate)/Polyvinylpyrrolidone Antifungal Materials Prospective as Active Dressings against Esca

Esca is a grapevine disease known for centuries which pertains to the group of so-called vine trunk diseases. Phaeomoniella chlamydospora (P. chlamydospora) and Phaeoacremonium aleophilum (P. aleophilum) are the two main fungal pathogens associated with esca. Novel fibrous materials with antifungal properties based on poly(3-hydroxybutyrate) (PHB), polyvinylpyrrolidone (PVP) and 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ) were developed. One-pot electrospinning (“in” strategy) or electrospinning in conjunction with electrospraying (“on” strategy) were applied to obtain the materials.
The materials’ morphology and their surface chemical composition were examined using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). CQ incorporated in the bulk of the fibers or in PVP particles deposited on the fibers was in the amorphous phase, which was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction analysis (XRD). The in vitro release of CQ depended on the composition of the electrospun materials and on their design.
The performed microbiological screening revealed that, unlike the non-loaded mats, the fibrous mats loaded with CQ were effective in inhibiting the growth of the pathogenic P. chlamydospora and P. aleophilum fungi. Therefore, the created materials are promising as active dressings for grapevine protection against esca.

Acute Oral, Subacute, and Developmental Toxicity Profiling of Naphthalene 2-Yl, 2-Chloro, 5-Nitrobenzoate: Assessment Based on Stress Response, Toxicity, and Adverse Outcome Pathways

Photodynamic therapy mediated by nanoparticles Aluminum Chloro Phthalocyanine in oral squamous carcinoma cells

The aim of this study is to investigate the antineoplastic potential of photodynamic therapy (PDT) mediated by an aluminum-phthalocyanine chloride nanoemulsion (AlPc-NE), against an oral squamous cell carcinoma (OSCC) cell line in vitro. Both OSCC (SCC9) and A431 cell lines were studied in vitro. Four study groups were used: Group 1 (phosphate-buffered saline [PBS]), Group 2 (PBS + 28.3 J/cm2 irradiation), Group 3 (AlPc-NE alone), and Group 4 (AlPc-NE + 28.3 J/cm2 irradiation). To test the effect of PDT with AlPc-NE, cell viability, migration, and cell death assays were performed. Moreover, the expressions of Ki-67 and TP53 were evaluated using immunoassays. The results showed that PDT mediated by all AlPc-NE concentrations evaluated (i.e., 0.7, 0.35, and 0.17 nM AlPc) significantly reduced the viability of SCC9 cells. Migration and cell death assays also revealed that PDT with AlPc-NE significantly reduced the rate of migration and increased cell death compared to the control groups. In addition, it was found that PDT with AlPc-NE reduced Ki-67 and mutated TP53 immunoexpression. PDT with AlPc-NE is effective in reducing the viability and migration of SCC9. Moreover, PDT with AlPc-NE nanoemulsions reduces the cell proliferation and expression of mutant TP53.

Methyl Decanoate(Methyl Caprate)

M294845 Toronto Research Chemicals 2.5g 74 EUR


M181350 Toronto Research Chemicals 2.5g 800 EUR

Methyl 3-Methyl-2-butenoate

M322530 Toronto Research Chemicals 100g 52 EUR

Methyl 3-Methyl-3-(methylamino)butanoate

M322975 Toronto Research Chemicals 500mg 800 EUR

Methyl 2-Methyl-3-(methylamino)propanoate

M355788 Toronto Research Chemicals 250mg 92 EUR

Methyl 2-methyl-4-nitrobenzoate

20-abx182527 Abbexa
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  • 25 g
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Methyl 2-Methyl-3-nitrobenzoate

M320165 Toronto Research Chemicals 100g 158 EUR

Methyl 6-Methyl-3-oxoheptanoate

M100120 Toronto Research Chemicals 2.5g 800 EUR

Methyl Acrylamidoglycolate Methyl Ester

M275800 Toronto Research Chemicals 5g 1200 EUR

Methyl 4-Methyl-3-hydroxybenzoate

M322970 Toronto Research Chemicals 10g 58 EUR

Methyl 2-methyl-2-phenylpropanoate

20-abx186702 Abbexa
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Methyl 4-Methyl-6-phenylpicolinate

M338403 Toronto Research Chemicals 100mg 4500 EUR

Methyl 2-Methyl-3-sulfanylpropanoate

M355805 Toronto Research Chemicals 250mg 1200 EUR

Loxoprofen methyl-d3 /-methyl ester

C109162 Toronto Research Chemicals 100mg 11200 EUR

Methyl 3-Methyl-4-Pyridinecarboxylate

20-abx182537 Abbexa
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Methyl-4-hydroxybenzoate (Methyl paraben)

M0572 Bio Basic 100g 93.41 EUR

Methyl[(1-methyl-1H-pyrazol-5-yl)methyl]amine Hydrochloride

M356225 Toronto Research Chemicals 1g 1200 EUR

Crystal structure and Hirshfeld surface analysis of 6-(( E)-2-{4-[2-(4-chloro-phen-yl)-2-oxoeth-oxy]phen-yl}ethen-yl)-4,5-di-hydro-pyridazin-3(2 H)-one

The pyridazine ring in the title compound, C20H17ClN2O3, adopts a screw-boat conformation. The whole mol-ecule is flattened, the dihedral angles subtended by the least-squares plane of the central aromatic ring with those of the terminal benzene and pyridazine rings being 15.18 (19) and 11.23 (19)°, respectively. In the crystal, the mol-ecules are linked by pairs of N-H⋯O bonds into centrosymmetric dimers and by C-H⋯π contacts into columns. The results of the Hirshfeld surface analysis show that the most prominent inter-actions are H⋯H, accounting for 36.5% of overall crystal packing, and H⋯O/O⋯H (18.6% contribution) contacts.
Christopher Miller