A Transgenic Heavy Chain IgG Mouse Platform as a Source of High Affinity Fully Human Single-Domain Antibodies for Therapeutic Applications

The antibody repertoires of transgenic mice expressing human heavy chain only antibodies (HCAbs) can be retrieved from immune cells after antigen challenge. Compared with genetically modified rodents expressing conventional human antibodies (tetramers consisting of two heavy chains paired with two light chains), there is no chain pairing problem, since each antibody consists of a heavy…

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pureexo exosome isolation kit

pureexo exosome isolation kit

Further Data Product Tags Cat. No. BL-P100 PureExo Cell Producer 101Bio Key Options Straightforward to make use of: No ultra-centrifugation (< 2 hours) 10 fold greater yield (vs. different kits and ultracentrifuge) Save value (vs. antibodies-beads methodology) Isolate Pure exosome (>95%) Intact exosome (good morphology) Use as little as 2 mL cell media to realize…

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computablegenomix

epigentek methylflash methylated dna quantification kit

Product Overview The MethylFlash Methylated DNA Quantification Package (Fluorometric) is a whole set of optimized buffers and reagents to fluorometrically quantify international DNA methylation by particularly measuring ranges of 5-methylcytosine (5-mC) in a microplate-based format. In comparison with LUMA or LINE-1, Alu, and LTR-based assays, MethylFlash™ expertise straight quantifies precise international DNA methylation. This equipment can also be particularly optimized for…

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computablegenomix

Chondrex: Arthritis and Inflammation Research Products

Chondrex, Inc. is happy to announce that we’re a brand new distributor for TdB Labs! TdB Labs has manufactured and supplied fluorescent and nonflurorescent dextran derivatives and different polysaccharides for the previous thirty years. Chondrex, Inc. is proud to distribute TdB Labs’s top quality and dependable merchandise alongside our personal merchandise worldwide. Chondrex, Inc. is happy to announce…

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computablegenomix

Current Practices for Reference Gene Selection in RT-qPCR of Aspergillus: Outlook and Recommendations for the Future

Aspergillus is a genus of filamentous fungi with huge geographic and ecological distributions. Species inside this genus are clinically, agriculturally and biotechnologically related, resulting in growing curiosity in elucidating gene expression dynamics of key metabolic and physiological processes. Reverse-transcription quantitative Polymerase Chain Response (RT-qPCR) is a delicate and particular methodology of quantifying gene expression. A vital…

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computablegenomix

Direct RT-qPCR assay for SARS-CoV-2 variants of concern (Alpha, B.1.1.7 and Beta, B.1.351) detection and quantification in wastewater

Lower than a 12 months following the Extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, variants of concern have emerged within the type of variant Alpha (B.1.1.7, the British variant) and Beta (B.1.351, the South Africa variant). Resulting from their excessive infectivity and morbidity, it has grow to be clear that it’s essential to rapidly…

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computablegenomix

Comparison of SARS-CoV-2 Detection by Rapid Antigen and by Three Commercial RT-qPCR Tests: A Study from Martin University Hospital in Slovakia

The worldwide pandemic of coronavirus illness 2019 (COVID-19) brought on by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is having an incredible affect on the worldwide financial system, well being care programs and the lives of virtually all folks on this planet. The Central European nation of Slovakia reached one of many highest day…

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computablegenomix

Comparison between Whatman FTA Elute Cards and Conventional Swab for the Detection of Pathogenic Enteric Bacteria Using an RT-qPCR Assay

The emergence of outbreaks of foodborne sickness is carefully related to meals contamination attributable to varied enteric pathogens, resembling Escherichia coli O157:H7, Listeria monocytogenes, Salmonella enterica serovar Enteritidis, and Staphylococcus aureus. The management of enteric pathogens poses a problem attributable to the truth that these pathogens can persist for an extended time frame within the surroundings. The fast detection of pathogenic…

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computablegenomix

A novel multiplex qPCR method for assessing the comparative lengths of telomeres

Background: The comparative size of telomeres is taken into account to be associated to illnesses similar to most cancers, growing old, and cardiovascular illnesses. qPCR is at the moment one of many fundamental strategies for detecting telomere size. Nevertheless, because of the distinctive sequence of telomeres (extremely repetitive six-base sequence), it’s troublesome to design primers and…

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computablegenomix

Normalization of SARS-CoV-2 viral load via RT-qPCR provides higher-resolution data for comparison across time and between patients

The 2020 pandemic has reworked the world and elicited hundreds of research to raised perceive the SARS-CoV-2 virus. Viral load has been a typical measure to observe remedy therapies and affiliate viral dynamics with affected person outcomes; nevertheless, strategies related to viral load have diverse throughout research. These variations have the potential to sacrifice the…

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